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A May 22, 2006 Reuters Health article reported on a Spanish study suggesting that common painkillers in the category of non-steroidal anti-inflammatory drugs (NSAIDs), including over-the-counter options like ibuprofen and naproxen, may increase the risk of first-time hospitalization for heart failure.

In the study, Dr. Consuelo Huerta compared individuals aged 60 to 84 who were hospitalized for heart failure with a control group. The findings revealed that 14% of those hospitalized for heart failure were current NSAID users, compared to just 10% of those not using the drugs. After accounting for other heart failure risk factors, researchers concluded that NSAID use was associated with a 30% increased risk of being hospitalized for heart failure for the first time.

This result was termed a “considerable public health impact.” Interestingly, the study found that the dosage and duration of NSAID use did not seem to affect the level of increased risk. The article noted that individuals with a history of heart problems faced a greater risk of hospitalization when using NSAIDs.

The study corroborated previous research indicating that NSAIDs can worsen heart failure symptoms. However, this study added new findings: NSAIDs increase the risk of hospitalization for heart failure even in patients without a prior history of heart failure.